Anticonvulsant activity of a nonpeptide galanin receptor agonist

Galanin is a neuropeptide with a wide variety of biological functions, including that of a strong endogenous anticonvulsant. No nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin, a combinatorial library was designed, synthesize...

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Autori principali: Saar, Külliki, Mazarati, Andrey M., Mahlapuu, Riina, Hallnemo, Gerd, Soomets, Ursel, Kilk, Kalle, Hellberg, Sven, Pooga, Margus, Tolf, Bo-Ragnar, Shi, Tiejun S., Hökfelt, Tomas, Wasterlain, Claude, Bartfai, Tamas, Langel, Ülo
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC124541/
https://ncbi.nlm.nih.gov/pubmed/12011470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102163499
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