The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen

The three proteins that comprise anthrax toxin, edema factor (EF), lethal factor (LF), and protective antigen (PA), assemble at the mammalian cell surface into toxic complexes. After binding to its receptor, PA is proteolytically activated, yielding a carboxyl-terminal 63-kDa fragment (PA(63)) that...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Mogridge, Jeremy, Cunningham, Kristina, Lacy, D. Borden, Mourez, Michael, Collier, R. John
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2002
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11997437/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052160199
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