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AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization
Somatic hypermutation generates variants of antibody genes and underpins the affinity maturation of antibodies. It is restricted to the V-gene segments, and although it decays exponentially toward the 3′end, it includes recognizable hot spots. Although the detailed mechanism of hypermutation remains...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124518/ https://ncbi.nlm.nih.gov/pubmed/12011459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.092160999 |
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