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Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress

The long-term effect of exposure to DNA alkylating agents is entwined with the cell's genetic capacity for DNA repair and appropriate DNA damage responses. A unique combination of environmental exposure and deficiency in these responses can lead to genomic instability; this “gene–environment interac...

Celý popis

Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sobol, Robert W., Watson, David E., Nakamura, Jun, Yakes, F. Michael, Hou, Esther, Horton, Julie K., Ladapo, Joseph, Van Houten, Bennett, Swenberg, James A., Tindall, Kenneth R., Samson, Leona D., Wilson, Samuel H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124494/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11983862/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.092662499
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