Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress

The long-term effect of exposure to DNA alkylating agents is entwined with the cell's genetic capacity for DNA repair and appropriate DNA damage responses. A unique combination of environmental exposure and deficiency in these responses can lead to genomic instability; this “gene–environment in...

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Main Authors: Sobol, Robert W., Watson, David E., Nakamura, Jun, Yakes, F. Michael, Hou, Esther, Horton, Julie K., Ladapo, Joseph, Van Houten, Bennett, Swenberg, James A., Tindall, Kenneth R., Samson, Leona D., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC124494/
https://ncbi.nlm.nih.gov/pubmed/11983862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.092662499
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