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Probing solvent accessibility of amyloid fibrils by solution NMR spectroscopy

Amyloid is the result of an anomalous protein and peptide aggregation, leading to the formation of insoluble fibril deposits. At present, 18 human diseases have been associated with amyloid deposits—e.g., Alzheimer's disease and Prion-transmissible Spongiform Encephalopathies. The molecular str...

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Autors principals: Ippel, Johannes H., Olofsson, Anders, Schleucher, Jürgen, Lundgren, Erik, Wijmenga, Sybren S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC124346/
https://ncbi.nlm.nih.gov/pubmed/12072564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132098999
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