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The rate-limiting step in the folding of a large ribozyme without kinetic traps

A fundamental question in RNA folding is the nature of the rate-limiting step. Folding of large RNAs often is trapped by the need to undo misfolded structures, which precludes the study of the other, potentially more interesting aspects in the rate-limiting step, such as conformational search, metal...

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Autors principals: Fang, X.-W., Thiyagarajan, P., Sosnick, T. R., Pan, T.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC124294/
https://ncbi.nlm.nih.gov/pubmed/12084911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.142288399
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