A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway

The eukaryotic intra-S-phase checkpoint, which slows DNA synthesis in response to DNA damage, is poorly understood. Is DNA damage recognized directly, or indirectly through its effects on replication forks? Is the slowing of S phase in part because of competition between DNA synthesis and recombinat...

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Bibliografiske detaljer
Main Authors: Marchetti, Maria A., Kumar, Sanjay, Hartsuiker, Edgar, Maftahi, Mohamed, Carr, Antony M., Freyer, Greg A., Burhans, William C., Huberman, Joel A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC124255/
https://ncbi.nlm.nih.gov/pubmed/12032307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112702399
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