A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway

The eukaryotic intra-S-phase checkpoint, which slows DNA synthesis in response to DNA damage, is poorly understood. Is DNA damage recognized directly, or indirectly through its effects on replication forks? Is the slowing of S phase in part because of competition between DNA synthesis and recombinat...

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Detalhes bibliográficos
Main Authors: Marchetti, Maria A., Kumar, Sanjay, Hartsuiker, Edgar, Maftahi, Mohamed, Carr, Antony M., Freyer, Greg A., Burhans, William C., Huberman, Joel A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC124255/
https://ncbi.nlm.nih.gov/pubmed/12032307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112702399
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