A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway

The eukaryotic intra-S-phase checkpoint, which slows DNA synthesis in response to DNA damage, is poorly understood. Is DNA damage recognized directly, or indirectly through its effects on replication forks? Is the slowing of S phase in part because of competition between DNA synthesis and recombinat...

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Main Authors: Marchetti, Maria A., Kumar, Sanjay, Hartsuiker, Edgar, Maftahi, Mohamed, Carr, Antony M., Freyer, Greg A., Burhans, William C., Huberman, Joel A.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2002
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC124255/
https://ncbi.nlm.nih.gov/pubmed/12032307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112702399
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