A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway

The eukaryotic intra-S-phase checkpoint, which slows DNA synthesis in response to DNA damage, is poorly understood. Is DNA damage recognized directly, or indirectly through its effects on replication forks? Is the slowing of S phase in part because of competition between DNA synthesis and recombinat...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Marchetti, Maria A., Kumar, Sanjay, Hartsuiker, Edgar, Maftahi, Mohamed, Carr, Antony M., Freyer, Greg A., Burhans, William C., Huberman, Joel A.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2002
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124255/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12032307/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.112702399
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