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Revision of T cell receptor α chain genes is required for normal T lymphocyte development
To become mature αβ T cells, developing thymocytes must first assemble a T cell receptor (TCR) β chain gene encoding a TCRβ chain that forms a pre-TCR. These cells then need to generate a TCRα chain gene encoding a TCRα chain, which, when paired with the TCRβ chain, forms a selectable αβ TCR. Newly...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1242309/ https://ncbi.nlm.nih.gov/pubmed/16186502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505564102 |
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