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Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells

Primitive human hematopoietic cells have low endogenous telomerase activity, yet telomeres are not maintained. In contrast, ectopic telomerase expression in fibroblasts and other cells leads to telomere length maintenance or elongation. It is unclear whether this disparity can be attributed to telom...

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Bibliografiske detaljer
Main Authors: Wang, J. C. Y., Warner, J. K., Erdmann, N., Lansdorp, P. M., Harrington, L., Dick, J. E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242297/
https://ncbi.nlm.nih.gov/pubmed/16172394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504161102
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