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Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells

Primitive human hematopoietic cells have low endogenous telomerase activity, yet telomeres are not maintained. In contrast, ectopic telomerase expression in fibroblasts and other cells leads to telomere length maintenance or elongation. It is unclear whether this disparity can be attributed to telom...

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Detalhes bibliográficos
Main Authors: Wang, J. C. Y., Warner, J. K., Erdmann, N., Lansdorp, P. M., Harrington, L., Dick, J. E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242297/
https://ncbi.nlm.nih.gov/pubmed/16172394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504161102
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