High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area

BACKGROUND: Germline mutations in the BRCA1 and BRCA2 genes have been shown to account for the majority of hereditary breast and ovarian cancers. The purpose of our study was to estimate the incidence and spectrum of pathogenic mutations in BRCA1/2 genes in high-risk Czech families. METHODS: A total...

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Bibliografiske detaljer
Main Authors: Pohlreich, Petr, Zikan, Michal, Stribrna, Jana, Kleibl, Zdenek, Janatova, Marketa, Kotlas, Jaroslav, Zidovska, Jana, Novotny, Jan, Petruzelka, Lubos, Szabo, Csilla, Matous, Bohuslav
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242140/
https://ncbi.nlm.nih.gov/pubmed/16168118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1282
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