CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate

Germline alterations in many genes coding for proteins regulating DNA repair and DNA damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as pathogenic factors in hereditary cancer predisposition. The ATM-CHEK2-p53 axis has been documented as a backbone for DDR and hypothesi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cells
Hauptverfasser: Stolarova, Lenka, Kleiblova, Petra, Janatova, Marketa, Soukupova, Jana, Zemankova, Petra, Macurek, Libor, Kleibl, Zdenek
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763663/
https://ncbi.nlm.nih.gov/pubmed/33322746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9122675
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