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CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate
Germline alterations in many genes coding for proteins regulating DNA repair and DNA damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as pathogenic factors in hereditary cancer predisposition. The ATM-CHEK2-p53 axis has been documented as a backbone for DDR and hypothesi...
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| Publicado no: | Cells |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7763663/ https://ncbi.nlm.nih.gov/pubmed/33322746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9122675 |
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