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Mechanistic features of CAG•CTG repeat contractions in cultured cells revealed by a novel genetic assay
Trinucleotide repeats (TNRs) undergo high frequency mutagenesis to cause at least 15 neurodegenerative diseases. To understand better the molecular mechanisms of TNR instability in cultured cells, a new genetic assay was created using a shuttle vector. The shuttle vector contains a promoter-TNR-repo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1240116/ https://ncbi.nlm.nih.gov/pubmed/16199754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki880 |
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