Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy

Spinal muscular atrophy (SMA) is a motoneuron disease caused by reduced levels of survival motoneuron (SMN) protein. Previous studies have assigned SMN to uridine-rich small nuclear ribonucleoprotein particle (U snRNP) assembly, splicing, transcription, and RNA localization. Here, we have used gene...

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Detalhes bibliográficos
Main Authors: Winkler, Christoph, Eggert, Christian, Gradl, Dietmar, Meister, Gunter, Giegerich, Marieke, Wedlich, Doris, Laggerbauer, Bernhard, Fischer, Utz
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1240041/
https://ncbi.nlm.nih.gov/pubmed/16204184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.342005
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