Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy

Spinal muscular atrophy (SMA) is a motoneuron disease caused by reduced levels of survival motoneuron (SMN) protein. Previous studies have assigned SMN to uridine-rich small nuclear ribonucleoprotein particle (U snRNP) assembly, splicing, transcription, and RNA localization. Here, we have used gene...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Winkler, Christoph, Eggert, Christian, Gradl, Dietmar, Meister, Gunter, Giegerich, Marieke, Wedlich, Doris, Laggerbauer, Bernhard, Fischer, Utz
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2005
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1240041/
https://ncbi.nlm.nih.gov/pubmed/16204184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.342005
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