A Differentiation-dependent Splice Variant of Myosin Light Chain Kinase, MLCK1, Regulates Epithelial Tight Junction Permeability

Activation of Na(+)-nutrient cotransport leads to increased tight junction permeability in intestinal absorptive (villus) enterocytes. This regulation requires myosin II regulatory light chain (MLC) phosphorylation mediated by MLC kinase (MLCK). We examined the spatiotemporal segregation of MLCK iso...

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Main Authors: Clayburgh, Daniel R., Rosen, Shari, Witkowski, Edwina D., Wang, Fengjun, Blair, Stephanie, Dudek, Steven, Garcia, Joe G. N., Alverdy, John C., Turner, Jerrold R.
Format: Artigo
Sprog:Inglês
Udgivet: 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1237105/
https://ncbi.nlm.nih.gov/pubmed/15507455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M408822200
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