A Differentiation-dependent Splice Variant of Myosin Light Chain Kinase, MLCK1, Regulates Epithelial Tight Junction Permeability

Activation of Na(+)-nutrient cotransport leads to increased tight junction permeability in intestinal absorptive (villus) enterocytes. This regulation requires myosin II regulatory light chain (MLC) phosphorylation mediated by MLC kinase (MLCK). We examined the spatiotemporal segregation of MLCK iso...

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Bibliographic Details
Main Authors: Clayburgh, Daniel R., Rosen, Shari, Witkowski, Edwina D., Wang, Fengjun, Blair, Stephanie, Dudek, Steven, Garcia, Joe G. N., Alverdy, John C., Turner, Jerrold R.
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1237105/
https://ncbi.nlm.nih.gov/pubmed/15507455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M408822200
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