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Chromosomal aberrations induced by double strand DNA breaks

It has been suggested that introduction of double-strand DNA breaks into mammalian chromosomes can lead to gross chromosomal rearrangements through improper DNA repair. To study this phenomenon, we employed a model system in which a double-strand DNA break (DSB) can be produced in human cells in viv...

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Détails bibliographiques
Auteurs principaux: Varga, Tamas, Aplan, Peter D.
Format: Artigo
Langue:Inglês
Publié: 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1237002/
https://ncbi.nlm.nih.gov/pubmed/15935739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2005.05.004
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