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Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough

The Upf proteins are essential for nonsense-mediated mRNA decay (NMD). They have also been implicated in the modulation of translational fidelity at viral frameshift signals and premature termination codons. How these factors function in both mRNA turnover and translational control remains unclear....

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Autori principali: HARGER, JASON W., DINMAN, JONATHAN D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Copyright 2004 by RNA Society 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236997/
https://ncbi.nlm.nih.gov/pubmed/15388879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7120504
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