Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

Bone remodeling, comprising resorption of existing bone and de novo bone formation, is required for the maintenance of a constant bone mass. Prostaglandin (PG)E(2) promotes both bone resorption and bone formation. By infusing PGE(2) to mice lacking each of four PGE receptor (EP) subtypes, we have id...

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Autori principali: Yoshida, Keiji, Oida, Hiroji, Kobayashi, Takuya, Maruyama, Takayuki, Tanaka, Masaharu, Katayama, Teruaki, Yamaguchi, Kojiro, Segi, Eri, Tsuboyama, Tadao, Matsushita, Mutsumi, Ito, Kosei, Ito, Yoshiaki, Sugimoto, Yukihiko, Ushikubi, Fumitaka, Ohuchida, Shuichi, Kondo, Kigen, Nakamura, Takashi, Narumiya, Shuh
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC123690/
https://ncbi.nlm.nih.gov/pubmed/11917107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062053399
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