Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice

Rheumatoid arthritis is one of the most critical diseases that impair the quality of life of patients, but its pathogenesis has not yet been fully understood. Osteopontin (OPN) is an extracellular matrix protein containing Arg-Gly-Asp (RGD) sequence, which interacts with αvβ3 integrins, promotes cel...

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Autors principals: Yumoto, Kenji, Ishijima, Muneaki, Rittling, Susan R., Tsuji, Kunikazu, Tsuchiya, Yoko, Kon, Shigeyuki, Nifuji, Akira, Uede, Toshimitsu, Denhardt, David T., Noda, Masaki
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC123686/
https://ncbi.nlm.nih.gov/pubmed/11930008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052523599
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