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Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice

Rheumatoid arthritis is one of the most critical diseases that impair the quality of life of patients, but its pathogenesis has not yet been fully understood. Osteopontin (OPN) is an extracellular matrix protein containing Arg-Gly-Asp (RGD) sequence, which interacts with αvβ3 integrins, promotes cel...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yumoto, Kenji, Ishijima, Muneaki, Rittling, Susan R., Tsuji, Kunikazu, Tsuchiya, Yoko, Kon, Shigeyuki, Nifuji, Akira, Uede, Toshimitsu, Denhardt, David T., Noda, Masaki
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123686/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11930008/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052523599
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