Directed evolution of the site specificity of Cre recombinase
Cre recombinase from bacteriophage P1 recognizes a 34-bp recombination site, loxP, with exquisite sequence specificity and catalyzes the site-specific insertion, excision, or rearrangement of DNA. To better understand the molecular basis of protein–DNA recognition and generate recombinases with alte...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123623/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11904359/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.022039799 |
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