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Large Upward Bias in Estimation of Locus-Specific Effects from Genomewide Scans

The primary goal of a genomewide scan is to estimate the genomic locations of genes influencing a trait of interest. It is sometimes said that a secondary goal is to estimate the phenotypic effects of each identified locus. Here, it is shown that these two objectives cannot be met reliably by use of...

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Detalhes bibliográficos
Main Authors: Göring, Harald H. H., Terwilliger, Joseph D., Blangero, John
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Human Genetics 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1235546/
https://ncbi.nlm.nih.gov/pubmed/11593451
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