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Estimation of significance thresholds for genomewide association scans

The question of what significance threshold is appropriate for genomewide association studies is somewhat unresolved. Previous theoretical suggestions have yet to be validated in practice, whereas permutation testing does not resolve a discrepancy between the genomewide multiplicity of the experimen...

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Hlavní autoři: Dudbridge, Frank, Gusnanto, Arief
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573032/
https://ncbi.nlm.nih.gov/pubmed/18300295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20297
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