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Evidence for a cytopathogenicity determinant in HIV-1 Vpr

HIV-1 is cytopathic for CD4(+) T lymphocytes in vitro and this property of HIV-1 is generally considered to account for some of its in vivo cytopathogenicity. Thus, the extent of lymphocyte depletion correlates with the level of viremia whereas low levels of viral replication are typically associate...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Somasundaran, Mohan, Sharkey, Mark, Brichacek, Beda, Luzuriaga, Katherine, Emerman, Michael, Sullivan, John L., Stevenson, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123170/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093916/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.142313699
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