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Evidence for a cytopathogenicity determinant in HIV-1 Vpr

HIV-1 is cytopathic for CD4(+) T lymphocytes in vitro and this property of HIV-1 is generally considered to account for some of its in vivo cytopathogenicity. Thus, the extent of lymphocyte depletion correlates with the level of viremia whereas low levels of viral replication are typically associate...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Somasundaran, Mohan, Sharkey, Mark, Brichacek, Beda, Luzuriaga, Katherine, Emerman, Michael, Sullivan, John L., Stevenson, Mario
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123170/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093916/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.142313699
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