Sequence Variation within Botulinum Neurotoxin Serotypes Impacts Antibody Binding and Neutralization

The botulinum neurotoxins (BoNTs) are category A biothreat agents which have been the focus of intensive efforts to develop vaccines and antibody-based prophylaxis and treatment. Such approaches must take into account the extensive BoNT sequence variability; the seven BoNT serotypes differ by up to...

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Autores principales: Smith, T. J., Lou, J., Geren, I. N., Forsyth, C. M., Tsai, R., LaPorte, S. L., Tepp, W. H., Bradshaw, M., Johnson, E. A., Smith, L. A., Marks, J. D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Molecular Pathogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1231122/
https://ncbi.nlm.nih.gov/pubmed/16113261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.9.5450-5457.2005
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