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Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation
Inactivating mutations of the adenomatous polyposis coli gene (APC) or activating mutations of the β-catenin gene (CTNNB1) initiate colorectal neoplasia. To address the biochemical and physiologic effects of mutant β-catenin, we disrupted either the mutant or wild-type CTNNB1 allele in a human color...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The National Academy of Sciences
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC123056/ https://ncbi.nlm.nih.gov/pubmed/12060769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082240999 |
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