Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation

Inactivating mutations of the adenomatous polyposis coli gene (APC) or activating mutations of the β-catenin gene (CTNNB1) initiate colorectal neoplasia. To address the biochemical and physiologic effects of mutant β-catenin, we disrupted either the mutant or wild-type CTNNB1 allele in a human color...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chan, Timothy A., Wang, Zhenghe, Dang, Long H., Vogelstein, Bert, Kinzler, Kenneth W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123056/
https://ncbi.nlm.nih.gov/pubmed/12060769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082240999
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados