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Constitutive telomerase expression promotes mammary carcinomas in aging mice

Telomerase is up-regulated in the vast majority of human cancers and serves to halt the progressive telomere shortening that ultimately blocks would-be cancer cells from achieving a full malignant phenotype. In contrast to humans, the laboratory mouse possesses long telomeres and, even in early gene...

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Hlavní autoři: Artandi, Steven E., Alson, Scott, Tietze, Maja K., Sharpless, Norman E., Ye, Siqin, Greenberg, Roger A., Castrillon, Diego H., Horner, James W., Weiler, Sarah R., Carrasco, Ruben D., DePinho, Ronald A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC123043/
https://ncbi.nlm.nih.gov/pubmed/12034875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112515399
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