Constitutive telomerase expression promotes mammary carcinomas in aging mice

Telomerase is up-regulated in the vast majority of human cancers and serves to halt the progressive telomere shortening that ultimately blocks would-be cancer cells from achieving a full malignant phenotype. In contrast to humans, the laboratory mouse possesses long telomeres and, even in early gene...

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Detalhes bibliográficos
Main Authors: Artandi, Steven E., Alson, Scott, Tietze, Maja K., Sharpless, Norman E., Ye, Siqin, Greenberg, Roger A., Castrillon, Diego H., Horner, James W., Weiler, Sarah R., Carrasco, Ruben D., DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123043/
https://ncbi.nlm.nih.gov/pubmed/12034875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112515399
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