Constitutive telomerase expression promotes mammary carcinomas in aging mice

Telomerase is up-regulated in the vast majority of human cancers and serves to halt the progressive telomere shortening that ultimately blocks would-be cancer cells from achieving a full malignant phenotype. In contrast to humans, the laboratory mouse possesses long telomeres and, even in early gene...

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Main Authors: Artandi, Steven E., Alson, Scott, Tietze, Maja K., Sharpless, Norman E., Ye, Siqin, Greenberg, Roger A., Castrillon, Diego H., Horner, James W., Weiler, Sarah R., Carrasco, Ruben D., DePinho, Ronald A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2002
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC123043/
https://ncbi.nlm.nih.gov/pubmed/12034875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112515399
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