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T-bet regulates IgG class switching and pathogenic autoantibody production
A molecular understanding of the regulation of IgG class switching to IL-4-independent isotypes, particularly to IgG2a, remains largely unknown. The T-box transcription factor T-bet directly regulates Th1 lineage commitment by CD4 T cells, but its role in B lymphocytes has been largely unexplored. W...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122806/ https://ncbi.nlm.nih.gov/pubmed/11960012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082114899 |
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