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A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

Double-stranded RNA-mediated interference (RNAi) has recently emerged as a powerful reverse genetic tool to silence gene expression in multiple organisms including plants, Caenorhabditis elegans, and Drosophila. The discovery that synthetic double-stranded, 21-nt small interfering RNA triggers gene-...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Sui, Guangchao, Soohoo, Christina, Affar, El Bachir, Gay, Frédérique, Shi, Yujiang, Forrester, William C., Shi, Yang
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122801/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11960009/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.082117599
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