Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

Presenilins 1 and 2 are two homologous proteins that, when mutated, account for most early onset Alzheimer's disease. Several lines of evidence suggest that, among various functions, presenilins could modulate cell apoptotic responses. Here we establish that the overexpression of presenilin 2 (...

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Detaylı Bibliyografya
Asıl Yazarlar: Alves da Costa, Cristine, Paitel, Erwan, Mattson, Mark P., Amson, Robert, Telerman, Adam, Ancolio, Karine, Checler, Frédéric
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2002
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC122645/
https://ncbi.nlm.nih.gov/pubmed/11904448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062059899
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