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Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

Presenilins 1 and 2 are two homologous proteins that, when mutated, account for most early onset Alzheimer's disease. Several lines of evidence suggest that, among various functions, presenilins could modulate cell apoptotic responses. Here we establish that the overexpression of presenilin 2 (PS2)...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Alves da Costa, Cristine, Paitel, Erwan, Mattson, Mark P., Amson, Robert, Telerman, Adam, Ancolio, Karine, Checler, Frédéric
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122645/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11904448/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.062059899
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