Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

Presenilins 1 and 2 are two homologous proteins that, when mutated, account for most early onset Alzheimer's disease. Several lines of evidence suggest that, among various functions, presenilins could modulate cell apoptotic responses. Here we establish that the overexpression of presenilin 2 (PS2)...

Disgrifiad llawn

Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Alves da Costa, Cristine, Paitel, Erwan, Mattson, Mark P., Amson, Robert, Telerman, Adam, Ancolio, Karine, Checler, Frédéric
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 2002
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122645/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11904448/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.062059899
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!