Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication

Cyclooxygenase 2 (COX-2) mRNA, protein, and activity are transiently induced after infection of human fibroblasts with human cytomegalovirus. Prostaglandin E(2), the product of COX-2 activity, is transiently increased by a factor of >50 in cultures of virus-infected fibroblasts. Both specific (BMS-2...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Zhu, Hua, Cong, Jian-Ping, Yu, Deborah, Bresnahan, Wade A., Shenk, Thomas E.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122626/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867761/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052713799
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