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Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
CyaA is crucial for colonization by Bordetella pertussis, the etiologic agent of whooping cough. Here we report crystal structures of the adenylyl cyclase domain (ACD) of CyaA with the C-terminal domain of calmodulin. Four discrete regions of CyaA bind calcium-loaded calmodulin with a large buried c...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224690/ https://ncbi.nlm.nih.gov/pubmed/16138079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600800 |
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