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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. Our goals here were to test whether ascorbate killed cancer cells selectively, and if so, to determine mechanisms, using clinically relevant...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Qi, Espey, Michael Graham, Krishna, Murali C., Mitchell, James B., Corpe, Christopher P., Buettner, Garry R., Shacter, Emily, Levine, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224653/
https://ncbi.nlm.nih.gov/pubmed/16157892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506390102
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