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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. Our goals here were to test whether ascorbate killed cancer cells selectively, and if so, to determine mechanisms, using clinically relevant...

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Hlavní autoři: Chen, Qi, Espey, Michael Graham, Krishna, Murali C., Mitchell, James B., Corpe, Christopher P., Buettner, Garry R., Shacter, Emily, Levine, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224653/
https://ncbi.nlm.nih.gov/pubmed/16157892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506390102
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