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A requirement for sustained ERK signaling during thymocyte positive selection in vivo

It is unknown how the contrasting events of positive and negative selection can lead to the distinct biological outcomes of life or death. An increasing body of evidence suggests that the duration of extracellular signal-regulated kinase (ERK) signaling plays a role in thymocyte selection. However,...

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Autori principali: McNeil, Lisa K., Starr, Timothy K., Hogquist, Kristin A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224638/
https://ncbi.nlm.nih.gov/pubmed/16174747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505110102
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