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Kinase suppressor of Ras 1 (KSR1) is required for full ERK activation in thymocytes but not for thymocyte selection

The scaffold protein kinase suppressor of Ras 1 (KSR1) is critical for efficient activation of ERK in a number of cell types. Consistent with this, we observed a defect in ERK activation in thymocytes that lack KSR1. Interestingly, we found that the defect was much greater after PMA stimulation than...

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Main Authors: Filbert, Erin L., Nguyen, AnhCo, Markiewicz, Mary A., Fowlkes, B. J., Huang, Yina H., Shaw, Andrey S.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976810/
https://ncbi.nlm.nih.gov/pubmed/20865788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040349
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