The kinase inhibitor imatinib mesylate inhibits TNF-α production in vitro and prevents TNF-dependent acute hepatic inflammation

Imatinib exerts potent antileukemic effects in vitro and in vivo. Despite its well known antitumor activity, the potential of imatinib for the treatment of inflammatory diseases remains elusive so far. Our current report provides strong evidence that imatinib has potent antiinflammatory effects. It...

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Autors principals: Wolf, Anna Maria, Wolf, Dominik, Rumpold, Holger, Ludwiczek, Susanne, Enrich, Barbara, Gastl, Guenther, Weiss, Guenter, Tilg, Herbert
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224614/
https://ncbi.nlm.nih.gov/pubmed/16174751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501758102
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