Differential regulation of the p70 S6 kinase pathway by interferon α (IFNα) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells

The precise mechanisms by which imatinib mesylate (STI571) and interferon α (IFNα) exhibit antileukemic effects are not known. We examined the effects of IFNs or imatinib mesylate on signaling pathways regulating initiation of mRNA translation in BCR-ABL-expressing cells. Treatment of IFN-sensitive...

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Autori principali: Parmar, Simrit, Smith, Jessica, Sassano, Antonella, Uddin, Shahab, Katsoulidis, Efstratios, Majchrzak, Beata, Kambhampati, Suman, Eklund, Elizabeth A., Tallman, Martin S., Fish, Eleanor N., Platanias, Leonidas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2005
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895266/
https://ncbi.nlm.nih.gov/pubmed/15790787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-4003
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