Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

Lysosomal proteases generate peptides presented by class II MHC molecules to CD4(+) T cells. To determine whether specific lysosomal proteases might influence the outcome of a CD4(+) T cell–dependent autoimmune response, we generated mice that lack cathepsin L (Cat L) on the autoimmune diabetes-pron...

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Bibliographic Details
Main Authors: Maehr, René, Mintern, Justine D., Herman, Ann E., Lennon-Duménil, Ana-Maria, Mathis, Diane, Benoist, Christophe, Ploegh, Hidde L.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2005
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224301/
https://ncbi.nlm.nih.gov/pubmed/16184198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25485
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