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Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
Lysosomal proteases generate peptides presented by class II MHC molecules to CD4(+) T cells. To determine whether specific lysosomal proteases might influence the outcome of a CD4(+) T cell–dependent autoimmune response, we generated mice that lack cathepsin L (Cat L) on the autoimmune diabetes-pron...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
2005
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224301/ https://ncbi.nlm.nih.gov/pubmed/16184198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25485 |
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